• Thu. Jul 10th, 2025

The U.S. cities with the highest risk of illness

The U.S. cities with the highest risk of illness

A recent study by Soliant has identified the U.S. cities where residents face the greatest health risks. 

Factors such as poor air quality, high allergy rates, and the persistent spread of viruses like the common cold and flu have made certain areas major hotspots for illness.

The U.S. Cities with the Highest Health Risks

The analysis looked at the 100 most populated cities in the country and assessed risk levels using data on:

  • Seasonal allergies
  • Air quality
  • Asthma incidence
  • Spread of respiratory diseases
  • Germ presence in public spaces

The findings are particularly concerning for California residents, as three cities from the state topped the list:

  • Bakersfield, CA: Scoring 59.10 on the “germ index,” Bakersfield ranked first due to extremely poor air quality and high flu and cold activity. The city also has elevated asthma rates, compounding health risks for residents.
  • Fresno, CA: With a score of 57.89, Fresno closely follows Bakersfield. The city shares similar structural health challenges, with residents frequently suffering from allergy symptoms like sneezing, congestion, and watery eyes due to heavy pollution and pollen levels.
  • San Diego, CA: Known for its pleasant climate, San Diego nonetheless faces significant health challenges. Scoring 57.64, the city experiences high rates of seasonal allergies and cold-related illnesses, placing it third on the list.

Where Are the Healthiest Cities?

It’s not all bad news. The study also highlighted cities with the lowest health risks—places where environmental and sanitary conditions support public well-being. Topping this more favorable list are:

  • Tucson, AZ: With a score of just 33.23, Tucson benefits from low levels of public-space germs and relatively good air quality, reducing the spread of respiratory illnesses.
  • Provo, UT: Scoring 32.48, Provo is considered one of the healthiest environments in the nation, thanks to a combination of clean air and low viral activity.

Why Do These Environmental Differences Matter?

Environmental factors like air pollution have a direct impact on respiratory health, increasing the likelihood of allergies, asthma, and infectious diseases.

Population density and the cleanliness of public spaces also play a crucial role in the spread of germs. 

According to Soliant’s data, cities with the highest risk scores tend to have multiple overlapping risk factors, placing a heavier burden on public health systems.


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